Assay Detail
Binding
CHEMBL3049709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDHc in Pisum sativum Zhongwan-2 (pea) shoot mitochondria assessed as decrease in rate of NADH formation using sodium pyruvate as substrate preincubated for 25 min before substrate addition measured after 1 min by spectrophotometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pisum sativum |
| Tissue | Shoot |
| Subcellular | Mitochondria |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies of O,O-dimethyl α-(2,4-dichlorophenoxyacetoxy)ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.74 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2227911 | CLACYFOS | — | 1 | 4.74 |
| CHEMBL2227929 | — | — | 1 | - |
| CHEMBL367623 | 2,4-DICHLOROPHENOXYACETIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2227911 | CLACYFOS | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL2227929 | — | IC50 | = | 442000.0 | nM | - |
| CHEMBL367623 | 2,4-DICHLOROPHENOXYACETIC ACID | IC50 | > | 4530000.0 | nM | - |