Assay Detail
Binding
CHEMBL3054763
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Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In Vitro and In Vivo Characterization of Alpha-1A Selective Agonists and Their Utility for Stress Incontience
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.28 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326702 | — | — | 1 | 6.18 |
| CHEMBL111734 | — | — | 1 | 5.23 |
| CHEMBL2261355 | — | — | 1 | 5.14 |
| CHEMBL321644 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326702 | — | Kd | = | 660.69 | nM | 6.18 |
| CHEMBL111734 | — | Kd | = | 5888.44 | nM | 5.23 |
| CHEMBL2261355 | — | Kd | = | 7244.36 | nM | 5.14 |
| CHEMBL321644 | — | Kd | = | 27542.29 | nM | 4.56 |