Assay Detail
Functional
CHEMBL3054834
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Antiviral activity against Human poliovirus 1 strain Sabin infected African green monkey Vero76 cells assessed as reduction of virus-induced plaque reduction after 2 days by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Poliovirus 1 |
| Cell Type | Vero 76 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | 4.75 |
| CHEMBL2262347 | — | — | 1 | - |
| CHEMBL2262145 | — | — | 1 | - |
| CHEMBL2262345 | — | — | 1 | - |
| CHEMBL2262344 | — | — | 1 | - |
| CHEMBL2262348 | — | — | 1 | - |
| CHEMBL2262359 | — | — | 1 | - |
| CHEMBL2262357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2262347 | — | EC50 | > | 96000.0 | nM | - |
| CHEMBL2262145 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2262345 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2262344 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2262348 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2262359 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2262357 | — | EC50 | > | 100000.0 | nM | - |