Assay Detail
Functional
CHEMBL3054877
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Cytotoxicity against Homo sapiens (human) SK-N-MC cells after 72 hr by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.26 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2262118 | — | — | 1 | 4.34 |
| CHEMBL2262117 | — | — | 1 | 4.32 |
| CHEMBL2262305 | — | — | 1 | 4.29 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.24 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | 4.21 |
| CHEMBL2262116 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2262118 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL2262117 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL2262305 | — | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL140 | CURCUMIN | IC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL2262116 | — | IC50 | = | 69800.0 | nM | 4.16 |