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Assay Detail

CHEMBL3054945

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by trypan blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, chemical characterization of novel 1,3-dimethyl acridones as cytotoxic agents, and their DNA-binding studies
Sathish NK, GopKumar P, Rajendra Prasad VVS, Shanta Kumar SM, Mayur YC
Med Chem Res (2010) 19 : 674 -689
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.93 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL88 CYCLOPHOSPHAMIDE ANHYDROUS 4.0 1 6.80
CHEMBL2260211 1 5.40
CHEMBL2260210 1 5.34
CHEMBL2260224 1 5.18
CHEMBL2260212 1 5.10
CHEMBL2260219 1 5.10
CHEMBL2260223 1 5.07
CHEMBL2260222 1 5.05
CHEMBL2260220 1 4.95
CHEMBL2260218 1 4.71
CHEMBL2260215 1 4.54
CHEMBL2260221 1 4.46
CHEMBL2260217 1 4.46
CHEMBL2260216 1 4.36
CHEMBL2260214 1 4.26
CHEMBL2260213 1 4.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL88 CYCLOPHOSPHAMIDE ANHYDROUS IC50 = 160.0 nM 6.80
CHEMBL2260211 IC50 = 4000.0 nM 5.40
CHEMBL2260210 IC50 = 4560.0 nM 5.34
CHEMBL2260224 IC50 = 6670.0 nM 5.18
CHEMBL2260212 IC50 = 7980.0 nM 5.10
CHEMBL2260219 IC50 = 7870.0 nM 5.10
CHEMBL2260223 IC50 = 8450.0 nM 5.07
CHEMBL2260222 IC50 = 8960.0 nM 5.05
CHEMBL2260220 IC50 = 11230.0 nM 4.95
CHEMBL2260218 IC50 = 19670.0 nM 4.71
CHEMBL2260215 IC50 = 28540.0 nM 4.54
CHEMBL2260221 IC50 = 34360.0 nM 4.46
CHEMBL2260217 IC50 = 34560.0 nM 4.46
CHEMBL2260216 IC50 = 43860.0 nM 4.36
CHEMBL2260214 IC50 = 54360.0 nM 4.26
CHEMBL2260213 IC50 = 78900.0 nM 4.10