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Assay Detail

CHEMBL3056264

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Binding
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL ↗
66
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Type-1 angiotensin II receptor (CHEMBL3374) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

QSAR modeling of some substituted benzimidazole as Angotensin II AT1 receptor antagonist
Jain A, Chaturvedi SC
Med Chem Res (2010) 19 : 177 -185
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 66 5.95 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7632 — — 2 6.96
CHEMBL300451 — — 2 6.60
CHEMBL299597 — — 2 6.50
CHEMBL49980 — — 2 6.48
CHEMBL299340 — — 2 6.48
CHEMBL300861 — — 2 6.36
CHEMBL51508 — — 2 6.36
CHEMBL52398 — — 2 6.35
CHEMBL51340 — — 2 6.27
CHEMBL48242 — — 2 6.26
CHEMBL275304 — — 2 6.22
CHEMBL417196 — — 2 6.18
CHEMBL299753 — — 2 6.13
CHEMBL54194 — — 2 6.06
CHEMBL7641 — — 2 6.05
CHEMBL51349 — — 2 6.04
CHEMBL2261752 — — 2 6.04
CHEMBL299980 — — 2 5.96
CHEMBL51399 — — 2 5.96
CHEMBL52343 — — 2 5.96
CHEMBL49930 — — 2 5.92
CHEMBL53074 — — 2 5.89
CHEMBL301072 — — 2 5.86
CHEMBL299994 — — 2 5.82
CHEMBL298741 — — 2 5.62
CHEMBL300239 — — 2 5.58
CHEMBL51634 — — 2 5.55
CHEMBL48692 — — 2 5.51
CHEMBL52265 — — 2 5.47
CHEMBL51246 — — 2 5.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7632 — IC50 = 110.15 nM 6.96
CHEMBL300451 — IC50 = 250.03 nM 6.60
CHEMBL300451 — IC50 = 250.0 nM 6.60
CHEMBL299597 — IC50 = 317.69 nM 6.50
CHEMBL299597 — IC50 = 320.0 nM 6.50
CHEMBL49980 — IC50 = 330.0 nM 6.48
CHEMBL49980 — IC50 = 330.37 nM 6.48
CHEMBL299340 — IC50 = 328.1 nM 6.48
CHEMBL299340 — IC50 = 340.0 nM 6.47
CHEMBL51508 — IC50 = 440.05 nM 6.36
CHEMBL51508 — IC50 = 440.0 nM 6.36
CHEMBL300861 — IC50 = 440.55 nM 6.36
CHEMBL300861 — IC50 = 440.0 nM 6.36
CHEMBL52398 — IC50 = 450.0 nM 6.35
CHEMBL52398 — IC50 = 450.82 nM 6.35
CHEMBL51340 — IC50 = 540.0 nM 6.27
CHEMBL51340 — IC50 = 544.5 nM 6.26
CHEMBL48242 — IC50 = 550.81 nM 6.26
CHEMBL48242 — IC50 = 550.0 nM 6.26
CHEMBL275304 — IC50 = 600.0 nM 6.22
CHEMBL275304 — IC50 = 601.17 nM 6.22
CHEMBL417196 — IC50 = 660.69 nM 6.18
CHEMBL417196 — IC50 = 660.0 nM 6.18
CHEMBL299753 — IC50 = 740.0 nM 6.13
CHEMBL299753 — IC50 = 741.31 nM 6.13
CHEMBL54194 — IC50 = 870.0 nM 6.06
CHEMBL54194 — IC50 = 870.96 nM 6.06
CHEMBL7641 — IC50 = 900.0 nM 6.05
CHEMBL2261752 — IC50 = 912.01 nM 6.04
CHEMBL51349 — IC50 = 912.01 nM 6.04
CHEMBL7641 — IC50 = 901.57 nM 6.04
CHEMBL2261752 — IC50 = 910.0 nM 6.04
CHEMBL51349 — IC50 = 910.0 nM 6.04
CHEMBL52343 — IC50 = 1101.54 nM 5.96
CHEMBL299980 — IC50 = 1101.54 nM 5.96
CHEMBL51399 — IC50 = 1100.0 nM 5.96
CHEMBL51399 — IC50 = 1101.54 nM 5.96
CHEMBL299980 — IC50 = 1100.0 nM 5.96
CHEMBL52343 — IC50 = 1100.0 nM 5.96
CHEMBL7632 — IC50 = 1100.0 nM 5.96
CHEMBL49930 — IC50 = 1200.0 nM 5.92
CHEMBL53074 — IC50 = 1300.17 nM 5.89
CHEMBL49930 — IC50 = 1300.17 nM 5.89
CHEMBL53074 — IC50 = 1300.0 nM 5.89
CHEMBL301072 — IC50 = 1393.16 nM 5.86
CHEMBL301072 — IC50 = 1400.0 nM 5.85
CHEMBL299994 — IC50 = 1500.0 nM 5.82
CHEMBL299994 — IC50 = 1503.14 nM 5.82
CHEMBL298741 — IC50 = 2400.0 nM 5.62
CHEMBL298741 — IC50 = 2404.36 nM 5.62