Assay Detail
Binding
CHEMBL3056339
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Inhibition of aldose reductase (unknown origin)
36
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
QSAR study of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.27 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2260162 | — | — | 2 | 9.89 |
| CHEMBL2260155 | — | — | 2 | 9.82 |
| CHEMBL1645381 | — | — | 2 | 9.77 |
| CHEMBL2260152 | — | — | 2 | 9.59 |
| CHEMBL1645384 | — | — | 2 | 9.55 |
| CHEMBL2260158 | — | — | 2 | 9.31 |
| CHEMBL2260153 | — | — | 2 | 9.18 |
| CHEMBL2260163 | — | — | 2 | 9.09 |
| CHEMBL2260159 | — | — | 2 | 8.92 |
| CHEMBL2260161 | — | — | 2 | 8.88 |
| CHEMBL2260156 | — | — | 2 | 8.38 |
| CHEMBL2260160 | — | — | 2 | 8.21 |
| CHEMBL2260154 | — | — | 2 | 8.21 |
| CHEMBL1348329 | — | — | 2 | 8.05 |
| CHEMBL1645382 | — | — | 2 | 7.97 |
| CHEMBL1645380 | — | — | 2 | 7.97 |
| CHEMBL87706 | — | — | 2 | 7.70 |
| CHEMBL2260157 | — | — | 2 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2260162 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL2260155 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL1645381 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL2260152 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL1645384 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2260158 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL2260153 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL2260163 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL2260159 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL2260161 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL2260156 | — | IC50 | = | 4.17 | nM | 8.38 |
| CHEMBL2260154 | — | IC50 | = | 6.18 | nM | 8.21 |
| CHEMBL2260160 | — | IC50 | = | 6.14 | nM | 8.21 |
| CHEMBL1348329 | — | IC50 | = | 8.96 | nM | 8.05 |
| CHEMBL1645380 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL1645382 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL87706 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL2260157 | — | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL2260162 | — | IC50 | = | 130.02 | nM | 6.89 |
| CHEMBL2260155 | — | IC50 | = | 149.97 | nM | 6.82 |
| CHEMBL1645381 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL2260152 | — | IC50 | = | 260.02 | nM | 6.58 |
| CHEMBL1645384 | — | IC50 | = | 279.9 | nM | 6.55 |
| CHEMBL2260158 | — | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL2260153 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL2260163 | — | IC50 | = | 820.35 | nM | 6.09 |
| CHEMBL2260159 | — | IC50 | = | 1191.24 | nM | 5.92 |
| CHEMBL2260161 | — | IC50 | = | 1321.3 | nM | 5.88 |
| CHEMBL2260156 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL2260154 | — | IC50 | = | 6180.16 | nM | 5.21 |
| CHEMBL2260160 | — | IC50 | = | 6137.62 | nM | 5.21 |
| CHEMBL1348329 | — | IC50 | = | 8953.65 | nM | 5.05 |
| CHEMBL1645382 | — | IC50 | = | 10690.55 | nM | 4.97 |
| CHEMBL1645380 | — | IC50 | = | 10690.55 | nM | 4.97 |
| CHEMBL87706 | — | IC50 | = | 20183.66 | nM | 4.70 |
| CHEMBL2260157 | — | IC50 | = | 39084.09 | nM | 4.41 |