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Assay Detail

CHEMBL3056396

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to alpha1A adrenoreceptor in Rattus norvegicus (rat) CEC-treated hippocampus
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Alpha-1A adrenergic receptor (CHEMBL319)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

(+)-Cyclazosin Derivatives as 1-Adrenoceptor Antagonists
Sagratini G, Buccioni M, Gulini U, Marucci G, Melchiorre C, Leonardi A, Testa R, Giardina D
Med Chem Res (2004) 13 : 190 -199
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.73 7.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2261604 (+)-CYCLAZOSIN 1 7.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2261604 (+)-CYCLAZOSIN Ki = 18.62 nM 7.73