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Assay Detail

CHEMBL3056489

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Homo sapiens (human) SK-MEL cells by neutral red staining
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL
Confidence 1 — Organism
Curated By Autocuration

Target

SK-MEL (CHEMBL614914)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Al-Wabli RI, AboulWafa OM, Youssef KM
Med Chem Res (2012) 21 : 874 -890
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.98 6.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.26
CHEMBL2260079 1 5.32
CHEMBL2260091 1 5.16
CHEMBL2260089 1 5.12
CHEMBL2260076 1 5.12
CHEMBL2260073 1 5.07
CHEMBL2259872 1 4.94
CHEMBL2260084 DI-O-CHLOROACETYLCURCUMIN 1 4.90
CHEMBL2260080 1 4.90
CHEMBL2260081 1 4.88
CHEMBL140 CURCUMIN 3.0 1 4.86
CHEMBL2260082 1 4.84
CHEMBL2260092 1 4.82
CHEMBL2260077 1 4.82
CHEMBL2260088 1 4.82
CHEMBL2260087 1 4.82
CHEMBL2259642 ETHYL CURCUMIN 1 4.80
CHEMBL2260074 1 4.73
CHEMBL2259876 1 4.73
CHEMBL2260075 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 550.0 nM 6.26
CHEMBL2260079 IC50 = 4750.0 nM 5.32
CHEMBL2260091 IC50 = 7000.0 nM 5.16
CHEMBL2260089 IC50 = 7500.0 nM 5.12
CHEMBL2260076 IC50 = 7500.0 nM 5.12
CHEMBL2260073 IC50 = 8500.0 nM 5.07
CHEMBL2259872 IC50 = 11500.0 nM 4.94
CHEMBL2260084 DI-O-CHLOROACETYLCURCUMIN IC50 = 12500.0 nM 4.90
CHEMBL2260080 IC50 = 12500.0 nM 4.90
CHEMBL2260081 IC50 = 13300.0 nM 4.88
CHEMBL140 CURCUMIN IC50 = 13750.0 nM 4.86
CHEMBL2260082 IC50 = 14500.0 nM 4.84
CHEMBL2260092 IC50 = 15000.0 nM 4.82
CHEMBL2260077 IC50 = 15000.0 nM 4.82
CHEMBL2260088 IC50 = 15000.0 nM 4.82
CHEMBL2260087 IC50 = 15000.0 nM 4.82
CHEMBL2259642 ETHYL CURCUMIN IC50 = 16000.0 nM 4.80
CHEMBL2260074 IC50 = 18500.0 nM 4.73
CHEMBL2259876 IC50 = 18800.0 nM 4.73
CHEMBL2260075 IC50 = 23800.0 nM 4.62