Assay Detail
Binding
CHEMBL3056509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldose reductase (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Experimental validation and docking studies of flavone derivatives on aldose reductase involved in diabetic retinopathy, neuropathy, and nephropathy
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.53 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2263318 | — | — | 1 | 7.87 |
| CHEMBL66879 | COUMARIC ACID | — | 1 | 6.85 |
| CHEMBL239559 | ISOORIENTIN | — | 1 | 5.72 |
| CHEMBL454320 | TRICIN | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2263318 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL239559 | ISOORIENTIN | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL454320 | TRICIN | IC50 | = | 2030.0 | nM | 5.69 |