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Assay Detail

CHEMBL3056575

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to aryl hydrocarbon receptor (unknown origin)
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aryl hydrocarbon receptor (CHEMBL3201)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Quantitative structureactivity relationships for estimating the aryl hydrocarbon receptor binding affinities of resveratrol derivatives and the antioxidant activities of hydroxystilbenes
Rayne S, Goss CD, Forest K, Friesen KJ
Med Chem Res (2010) 19 : 864 -901
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.92 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL178967 2 7.92
CHEMBL426049 2 7.92
CHEMBL179243 2 7.92
CHEMBL361413 2 7.92
CHEMBL311636 8Z-3,4',5-TRIMETHOXYSTILBENE 2 7.92
CHEMBL178733 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL178967 Ki = 12.0 nM 7.92
CHEMBL426049 Ki = 12.0 nM 7.92
CHEMBL179243 Ki = 12.0 nM 7.92
CHEMBL361413 Ki = 12.0 nM 7.92
CHEMBL311636 8Z-3,4',5-TRIMETHOXYSTILBENE Ki = 12.0 nM 7.92
CHEMBL178967 Ki = 79432823.47 nM -
CHEMBL426049 Ki = 79432823.47 nM -
CHEMBL179243 Ki = 79432823.47 nM -
CHEMBL361413 Ki = 79432823.47 nM -
CHEMBL311636 8Z-3,4',5-TRIMETHOXYSTILBENE Ki = 79432823.47 nM -
CHEMBL178733 Ki = 831763771.1 nM -