Assay Detail
Binding
CHEMBL3056799
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Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
160
Total Activities
83
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quantitative structure activity relationship analysis of angiotensin II AT1 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 83 | 8.08 | 9.30 |
| log(1/C) | 77 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122969 | — | — | 2 | 9.30 |
| CHEMBL125725 | — | — | 2 | 9.30 |
| CHEMBL124925 | — | — | 2 | 9.22 |
| CHEMBL122443 | — | — | 2 | 9.22 |
| CHEMBL341295 | — | — | 2 | 9.22 |
| CHEMBL126111 | — | — | 2 | 9.15 |
| CHEMBL341131 | — | — | 2 | 9.05 |
| CHEMBL123671 | — | — | 2 | 8.92 |
| CHEMBL124913 | — | — | 2 | 8.92 |
| CHEMBL331042 | — | — | 2 | 8.89 |
| CHEMBL125542 | — | — | 2 | 8.85 |
| CHEMBL122966 | — | — | 2 | 8.82 |
| CHEMBL125383 | — | — | 2 | 8.77 |
| CHEMBL122638 | — | — | 2 | 8.72 |
| CHEMBL126037 | — | — | 2 | 8.64 |
| CHEMBL125766 | — | — | 2 | 8.62 |
| CHEMBL2259779 | — | — | 2 | 8.60 |
| CHEMBL123568 | — | — | 2 | 8.59 |
| CHEMBL125818 | — | — | 1 | 8.57 |
| CHEMBL125937 | — | — | 2 | 8.55 |
| CHEMBL2259780 | — | — | 2 | 8.52 |
| CHEMBL333411 | — | — | 2 | 8.52 |
| CHEMBL331519 | — | — | 2 | 8.48 |
| CHEMBL2259778 | — | — | 1 | 8.48 |
| CHEMBL121874 | — | — | 2 | 8.47 |
| CHEMBL331511 | — | — | 2 | 8.47 |
| CHEMBL121854 | — | — | 2 | 8.46 |
| CHEMBL331859 | — | — | 2 | 8.40 |
| CHEMBL419421 | — | — | 2 | 8.38 |
| CHEMBL125940 | — | — | 2 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125725 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL122969 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL122443 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL124925 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL341295 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL126111 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL341131 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL124913 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL123671 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL331042 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL125542 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL122966 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL125383 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL122638 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL126037 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL125766 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2259779 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL123568 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL125818 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL125937 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2259780 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL333411 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2259778 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL331519 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL121874 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL331511 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL121854 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL331859 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL125940 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL419421 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL339404 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL122982 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL332766 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL125533 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL122494 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2263317 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL341151 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL341070 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL125958 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL421074 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL331546 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL339544 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL333722 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL338514 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL122458 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL421629 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2263543 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL121718 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL125273 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL125454 | — | IC50 | = | 9.9 | nM | 8.00 |