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Assay Detail

CHEMBL3057004

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against Sus scrofa (pig) LLC-PK1 cells by neutral red staining
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Sus scrofa
Cell Type LLC-PK1
Confidence 1 — Organism
Curated By Autocuration

Target

LLC-PK1 (CHEMBL614577)
Type CELL-LINE
Organism Sus scrofa

Publication

Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Al-Wabli RI, AboulWafa OM, Youssef KM
Med Chem Res (2012) 21 : 874 -890
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.94 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.12
CHEMBL2259872 1 5.24
CHEMBL2260081 1 5.17
CHEMBL2260080 1 4.89
CHEMBL2260082 1 4.86
CHEMBL2260076 1 4.81
CHEMBL2259876 1 4.80
CHEMBL2260077 1 4.78
CHEMBL2260091 1 4.70
CHEMBL2260083 1 4.66
CHEMBL2260089 1 4.65
CHEMBL2260088 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 750.0 nM 6.12
CHEMBL2259872 IC50 = 5800.0 nM 5.24
CHEMBL2260081 IC50 = 6800.0 nM 5.17
CHEMBL2260080 IC50 = 13000.0 nM 4.89
CHEMBL2260082 IC50 = 13800.0 nM 4.86
CHEMBL2260076 IC50 = 15500.0 nM 4.81
CHEMBL2259876 IC50 = 15750.0 nM 4.80
CHEMBL2260077 IC50 = 16800.0 nM 4.78
CHEMBL2260091 IC50 = 20000.0 nM 4.70
CHEMBL2260083 IC50 = 22000.0 nM 4.66
CHEMBL2260089 IC50 = 22500.0 nM 4.65
CHEMBL2260088 IC50 = 22500.0 nM 4.65