Assay Detail
Binding
CHEMBL3057495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nicotine from Homo sapiens (human) alpha4beta2 nicotinic acetylcholine receptor expressed in Homo sapiens (human) SH-EP1 cells after 2.5 min by scintillation counting
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-EP1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Biososteric Replacement in the Design and Synthesis of Ligands for Nicotinic Acetylcholine Receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.95 | 6.52 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61616 | — | — | 1 | 6.52 |
| CHEMBL2261108 | — | — | 1 | 6.44 |
| CHEMBL113076 | — | — | 1 | 6.35 |
| CHEMBL2261107 | — | — | 1 | 5.47 |
| CHEMBL2261111 | — | — | 2 | 4.95 |
| CHEMBL2261112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61616 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2261108 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL113076 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2261107 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL2261111 | — | Ki | = | 11200.0 | nM | 4.95 |
| CHEMBL2261111 | — | Inhibition | - | % | - | |
| CHEMBL2261112 | — | Ki | - | — | - |