Assay Detail
Binding
CHEMBL3057497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha4beta2 nicotinic acetylcholine receptor (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Biososteric Replacement in the Design and Synthesis of Ligands for Nicotinic Acetylcholine Receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.81 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59986 | — | — | 1 | 10.40 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.15 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.98 |
| CHEMBL2261113 | — | — | 1 | 8.40 |
| CHEMBL2261114 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59986 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL3 | NICOTINE | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL2261113 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2261114 | — | Ki | = | 734.0 | nM | 6.13 |