Assay Detail
Binding
CHEMBL3057585
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Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rA)oligo(dT) template primer after 30 min
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.72 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.30 |
| CHEMBL2262683 | — | — | 1 | 5.47 |
| CHEMBL2262682 | — | — | 1 | 5.44 |
| CHEMBL84383 | — | — | 1 | 5.22 |
| CHEMBL2262681 | — | — | 1 | 5.15 |
| CHEMBL2262684 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2262683 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL2262682 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL84383 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL2262681 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2262684 | — | IC50 | = | 8370.0 | nM | 5.08 |