Assay Detail

CHEMBL3058111

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to histamine H2 receptor (unknown origin)

ChEMBL ↗

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Target

Histamine H2 receptor (CHEMBL1941) ↗

Open DB target context

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Histamine H2 receptor (CHEMBL1941) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histamine H2 receptor

CHEMBL1941

Anchored from Assay target.

Protein identity Histamine H2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histamine H2 receptor (CHEMBL1941) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Improgan-like Analgesics: A Family of Compounds Derived From Histamine Anatgonists

Hough L, Nalwalk J, Menge W, Leurs R, Timmerman H
Med Chem Res (2004) 13 : 78 -87
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	6.16	7.20

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1790041	RANITIDINE	4.0	1	7.20
CHEMBL12160	BURIMAMIDE	—	1	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1790041	RANITIDINE	Kd	=	63.0	nM	7.20
CHEMBL12160	BURIMAMIDE	Kd	=	7800.0	nM	5.11