Assay Detail
Binding
CHEMBL3058311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(+)-Cyclazosin Derivatives as 1-Adrenoceptor Antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.05 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2261604 | (+)-CYCLAZOSIN | — | 1 | 7.27 |
| CHEMBL2261605 | — | — | 1 | 7.23 |
| CHEMBL2261607 | — | — | 1 | 7.05 |
| CHEMBL2261606 | — | — | 1 | 7.04 |
| CHEMBL2261608 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2261604 | (+)-CYCLAZOSIN | Kd | = | 53.7 | nM | 7.27 |
| CHEMBL2261605 | — | Kd | = | 58.88 | nM | 7.23 |
| CHEMBL2261607 | — | Kd | = | 89.13 | nM | 7.05 |
| CHEMBL2261606 | — | Kd | = | 91.2 | nM | 7.04 |
| CHEMBL2261608 | — | Kd | = | 213.8 | nM | 6.67 |