Assay Detail
Binding
CHEMBL3058320
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Displacement of [3H]prazosin from Homo sapiens (human) alpha1A adrenergic receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(+)-Cyclazosin Derivatives as 1-Adrenoceptor Antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.83 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2261605 | — | — | 1 | 8.46 |
| CHEMBL2261604 | (+)-CYCLAZOSIN | — | 1 | 7.91 |
| CHEMBL2261606 | — | — | 1 | 7.63 |
| CHEMBL2261608 | — | — | 1 | 7.59 |
| CHEMBL2261607 | — | — | 1 | 7.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2261605 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL2261604 | (+)-CYCLAZOSIN | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL2261606 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL2261608 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL2261607 | — | Ki | = | 27.54 | nM | 7.56 |