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Assay Detail

CHEMBL3060544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protoporphyrinogen IX oxidase in Zea mays cv. Anjou (maize) seedlings etioplasts homogenates assessed as reduction in protoporphyrin IX production by fluorescence spectroscopy
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zea mays
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protoporphyrinogen IX oxidase (CHEMBL2366512)
Type SINGLE PROTEIN
Organism Zea mays

Publication

Peroxidizing Phytotoxic Activity of 1, 3, 4-Thiadiazolidine-2-thiones and 1, 2, 4-Triazolidine-3, 5-dithiones
IHARA T, IIDA T, TAKASUKA S, KOHNO H, SATO Y, NICOLAUS B, BOGER P, WAKABAYASHI K
J Pestic Sci (1995) 20 : 41 -47
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.99 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2268924 1 8.92
CHEMBL2268934 1 8.17
CHEMBL2268922 1 8.14
CHEMBL2268935 1 8.14
CHEMBL1871400 OXYFLUORFEN 1 8.10
CHEMBL2268923 1 8.05
CHEMBL2268936 1 7.92
CHEMBL2268932 1 6.92
CHEMBL2268921 1 6.82
CHEMBL2268930 1 6.69
CHEMBL2268931 1 6.21
CHEMBL2268926 1 6.13
CHEMBL2268927 1 6.09
CHEMBL2268929 1 5.96
CHEMBL2268938 1 5.96
CHEMBL2268933 1 5.49
CHEMBL2268928 1 5.12
CHEMBL2268937 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2268924 IC50 = 1.202 nM 8.92
CHEMBL2268934 IC50 = 6.761 nM 8.17
CHEMBL2268922 IC50 = 7.244 nM 8.14
CHEMBL2268935 IC50 = 7.244 nM 8.14
CHEMBL1871400 OXYFLUORFEN IC50 = 7.943 nM 8.10
CHEMBL2268923 IC50 = 8.913 nM 8.05
CHEMBL2268936 IC50 = 12.02 nM 7.92
CHEMBL2268932 IC50 = 120.23 nM 6.92
CHEMBL2268921 IC50 = 151.36 nM 6.82
CHEMBL2268930 IC50 = 204.17 nM 6.69
CHEMBL2268931 IC50 = 616.6 nM 6.21
CHEMBL2268926 IC50 = 741.31 nM 6.13
CHEMBL2268927 IC50 = 812.83 nM 6.09
CHEMBL2268929 IC50 = 1096.48 nM 5.96
CHEMBL2268938 IC50 = 1096.48 nM 5.96
CHEMBL2268933 IC50 = 3235.94 nM 5.49
CHEMBL2268928 IC50 = 7585.78 nM 5.12
CHEMBL2268937 IC50 > 31622.78 nM -