Assay Detail
Binding
CHEMBL3061795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Acinetobacter baumannii beta-lactamase SHV-48
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Acinetobacter baumannii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Extended-spectrum beta-lactamase SHV-48 (CHEMBL2233620) ↗| Type | SINGLE PROTEIN |
| Organism | Acinetobacter baumannii |
Publication
Homology modeling and docking study of recent SHV type -lactamses with traditional and novel inhibitors: an in silico approach to combat problem of multiple drug resistance in various infections
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.48 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2236666 | — | — | 1 | 4.72 |
| CHEMBL1673092 | PENEM-2 | — | 1 | 4.46 |
| CHEMBL1673091 | PENEM-1 | — | 1 | 4.26 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2236666 | — | Ki | = | 19020.0 | nM | 4.72 |
| CHEMBL1673092 | PENEM-2 | Ki | = | 34670.0 | nM | 4.46 |
| CHEMBL1673091 | PENEM-1 | Ki | = | 54370.0 | nM | 4.26 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 227360.0 | nM | - |