Assay Detail
Functional
CHEMBL3061850
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Cytotoxicity against Homo sapiens (human) Hep2 cells after 48 hr by SRB assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 5.19 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.96 |
| CHEMBL2237654 | — | — | 1 | 6.77 |
| CHEMBL1684764 | — | — | 1 | 6.72 |
| CHEMBL2237898 | — | — | 1 | 6.28 |
| CHEMBL2237899 | — | — | 1 | 6.23 |
| CHEMBL1684759 | — | — | 1 | 6.00 |
| CHEMBL2237901 | — | — | 1 | 6.00 |
| CHEMBL2237895 | — | — | 1 | 6.00 |
| CHEMBL1684758 | — | — | 1 | 5.99 |
| CHEMBL2237902 | — | — | 1 | 5.99 |
| CHEMBL1684763 | — | — | 1 | 5.97 |
| CHEMBL2237900 | — | — | 1 | 5.96 |
| CHEMBL1684761 | — | — | 1 | 5.95 |
| CHEMBL2237905 | — | — | 1 | 5.89 |
| CHEMBL1684757 | — | — | 1 | 5.88 |
| CHEMBL2237653 | — | — | 1 | 5.49 |
| CHEMBL1684638 | — | — | 1 | 5.45 |
| CHEMBL2237896 | — | — | 1 | 5.44 |
| CHEMBL1684754 | — | — | 1 | 5.43 |
| CHEMBL2237894 | — | — | 1 | 5.41 |
| CHEMBL1684756 | — | — | 1 | 5.40 |
| CHEMBL1684753 | — | — | 1 | 5.39 |
| CHEMBL1224508 | — | — | 1 | 5.34 |
| CHEMBL1684637 | — | — | 1 | 5.30 |
| CHEMBL1542147 | — | — | 1 | 5.18 |
| CHEMBL1684776 | — | — | 1 | 5.17 |
| CHEMBL1684646 | — | — | 1 | 5.12 |
| CHEMBL562142 | — | — | 1 | 5.11 |
| CHEMBL1684644 | — | — | 1 | 5.11 |
| CHEMBL1684643 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2237654 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1684764 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2237898 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2237899 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1684759 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL2237901 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL2237895 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1684758 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2237902 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1684763 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2237900 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1684761 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL2237905 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1684757 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL2237653 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL1684638 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL2237896 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL1684754 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL2237894 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL1684756 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL1684753 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL1224508 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL1684637 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL1542147 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL1684776 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL1684646 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL562142 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL1684644 | — | IC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL1684643 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL2237893 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2237903 | — | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL1684641 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL1684639 | — | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL1684642 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL1684768 | — | IC50 | = | 10020.0 | nM | 5.00 |
| CHEMBL1684755 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL1684777 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL1684775 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL1209130 | — | IC50 | = | 10680.0 | nM | 4.97 |
| CHEMBL1684751 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL193585 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL2237897 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL1684773 | — | IC50 | = | 13340.0 | nM | 4.88 |
| CHEMBL1684635 | — | IC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL1684771 | — | IC50 | = | 15640.0 | nM | 4.81 |
| CHEMBL1684772 | — | IC50 | = | 15980.0 | nM | 4.80 |
| CHEMBL1684762 | — | IC50 | = | 16760.0 | nM | 4.78 |
| CHEMBL2237656 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1209915 | — | IC50 | = | 17870.0 | nM | 4.75 |