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Assay Detail

CHEMBL3061900

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Homo sapiens (human) NALM6 cells assessed as reduction in cell survival fraction after 48 hr by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NALM-6
Confidence 1 — Organism
Curated By Autocuration

Target

NALM-6 (CHEMBL614187)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone
azarenkow A, Nawrot-Modranka J, Brzezinska E, Krajewska U, Rozalski M
Med Chem Res (2012) 21 : 1861 -1868
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.29 4.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2234948 1 4.55
CHEMBL2234940 1 4.54
CHEMBL2234946 1 4.38
CHEMBL2234939 1 4.25
CHEMBL2234947 1 4.18
CHEMBL2234938 1 4.18
CHEMBL1464 WARFARIN 4.0 1 4.13
CHEMBL2234941 1 4.07
CHEMBL2234949 1 -
CHEMBL2234945 1 -
CHEMBL2234944 1 -
CHEMBL2234943 1 -
CHEMBL2234942 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2234948 IC50 = 28000.0 nM 4.55
CHEMBL2234940 IC50 = 28800.0 nM 4.54
CHEMBL2234946 IC50 = 42100.0 nM 4.38
CHEMBL2234939 IC50 = 56500.0 nM 4.25
CHEMBL2234947 IC50 = 65300.0 nM 4.18
CHEMBL2234938 IC50 = 66500.0 nM 4.18
CHEMBL1464 WARFARIN IC50 = 74800.0 nM 4.13
CHEMBL2234941 IC50 = 85300.0 nM 4.07
CHEMBL2234949 IC50 = 101900.0 nM -
CHEMBL2234945 IC50 = 627700.0 nM -
CHEMBL2234944 IC50 = 407100.0 nM -
CHEMBL2234943 IC50 = 499900.0 nM -
CHEMBL2234942 IC50 = 309200.0 nM -