Assay Detail
Binding
CHEMBL3062224
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Binding affinity to Homo sapiens (human) alpha1A adrenergic receptor
40
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3D-QSAR STUDIES ON SUBSTITUTED DIHYDROPYRIDINES FOR THEIR 1A-ADRENERGIC RECEPTOR BINDING AFFINITY
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 8.30 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2260360 | — | — | 1 | 9.64 |
| CHEMBL5483012 | — | — | 1 | 9.46 |
| CHEMBL2260370 | — | — | 1 | 9.28 |
| CHEMBL279436 | — | — | 3 | 9.00 |
| CHEMBL91550 | — | — | 1 | 8.97 |
| CHEMBL2260366 | — | — | 1 | 8.95 |
| CHEMBL89685 | — | — | 1 | 8.93 |
| CHEMBL2260365 | — | — | 1 | 8.86 |
| CHEMBL2260368 | — | — | 1 | 8.83 |
| CHEMBL2260359 | — | — | 1 | 8.75 |
| CHEMBL2260149 | — | — | 1 | 8.74 |
| CHEMBL2260367 | — | — | 1 | 8.73 |
| CHEMBL347499 | — | — | 1 | 8.72 |
| CHEMBL146815 | — | — | 1 | 8.59 |
| CHEMBL2260362 | — | — | 1 | 8.45 |
| CHEMBL2260364 | — | — | 1 | 8.44 |
| CHEMBL2260363 | — | — | 1 | 8.43 |
| CHEMBL147077 | — | — | 1 | 8.40 |
| CHEMBL148552 | — | — | 1 | 8.38 |
| CHEMBL284103 | — | — | 1 | 8.35 |
| CHEMBL357681 | — | — | 1 | 8.32 |
| CHEMBL2260361 | — | — | 1 | 8.32 |
| CHEMBL355910 | — | — | 1 | 8.21 |
| CHEMBL358253 | — | — | 1 | 8.21 |
| CHEMBL2260150 | — | — | 1 | 8.15 |
| CHEMBL149263 | — | — | 1 | 8.11 |
| CHEMBL2260371 | — | — | 1 | 8.06 |
| CHEMBL312871 | — | — | 1 | 8.06 |
| CHEMBL88388 | — | — | 1 | 8.05 |
| CHEMBL2260147 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2260360 | — | Ki | = | 0.2291 | nM | 9.64 |
| CHEMBL5483012 | — | Ki | = | 0.3467 | nM | 9.46 |
| CHEMBL2260370 | — | Ki | = | 0.5248 | nM | 9.28 |
| CHEMBL279436 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL91550 | — | Ki | = | 1.072 | nM | 8.97 |
| CHEMBL2260366 | — | Ki | = | 1.122 | nM | 8.95 |
| CHEMBL89685 | — | Ki | = | 1.175 | nM | 8.93 |
| CHEMBL2260365 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL2260368 | — | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL2260359 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL2260149 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL2260367 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL279436 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL347499 | — | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL146815 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL2260362 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL2260364 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL2260363 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL147077 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL148552 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL284103 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL2260361 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL357681 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL358253 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL355910 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL2260150 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL149263 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL2260371 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL312871 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL88388 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL2260147 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL88628 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL2260148 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL279436 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL2260369 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL313953 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL327775 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL315392 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL151668 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL313251 | — | Ki | = | 316.23 | nM | 6.50 |