Assay Detail
Binding
CHEMBL3062604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectrophotometric analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Molecular modeling studies, synthesis and biological evaluation of derivatives of N-phenylbenzamide as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.41 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2234185 | — | — | 1 | 7.00 |
| CHEMBL2234186 | — | — | 1 | 7.00 |
| CHEMBL2234188 | — | — | 1 | 7.00 |
| CHEMBL2234182 | — | — | 1 | 7.00 |
| CHEMBL2234183 | — | — | 1 | 6.82 |
| CHEMBL217893 | — | — | 1 | 6.82 |
| CHEMBL2234187 | — | — | 1 | 6.82 |
| CHEMBL1331783 | — | — | 1 | 6.70 |
| CHEMBL2234191 | — | — | 1 | 6.60 |
| CHEMBL2234189 | — | — | 1 | 6.60 |
| CHEMBL2234184 | — | — | 1 | 6.60 |
| CHEMBL2234190 | — | — | 1 | 6.52 |
| CHEMBL2234192 | — | — | 1 | 6.26 |
| CHEMBL199572 | — | — | 1 | 4.37 |
| CHEMBL372561 | — | — | 1 | 4.03 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | - |
| CHEMBL370865 | — | — | 1 | - |
| CHEMBL199574 | — | — | 1 | - |
| CHEMBL141040 | — | — | 1 | - |
| CHEMBL344556 | — | — | 1 | - |
| CHEMBL141732 | — | — | 1 | - |
| CHEMBL141195 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2234185 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2234186 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2234188 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2234182 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2234183 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL217893 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL2234187 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL1331783 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2234191 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2234189 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2234184 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2234190 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL2234192 | — | IC50 | = | 549.54 | nM | 6.26 |
| CHEMBL199572 | — | IC50 | = | 42657.95 | nM | 4.37 |
| CHEMBL372561 | — | IC50 | = | 93325.43 | nM | 4.03 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 190546.07 | nM | - |
| CHEMBL370865 | — | IC50 | = | 154881.66 | nM | - |
| CHEMBL199574 | — | IC50 | = | 141253.75 | nM | - |
| CHEMBL141040 | — | IC50 | = | 870963.59 | nM | - |
| CHEMBL344556 | — | IC50 | = | 537031.8 | nM | - |
| CHEMBL141732 | — | IC50 | = | 1071519.31 | nM | - |
| CHEMBL141195 | — | IC50 | = | 707945.78 | nM | - |