Assay Detail
Binding
CHEMBL3067866
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Binding affinity to recombinant Gallus gallus (chicken) alpha4beta2 nicotinic acetylcholine receptor assessed as [3H]NIC binding by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-4 (CHEMBL5569) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Unique neonicotinoid binding conformations conferring selective receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.92 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 11.00 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | — | 1 | 8.92 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.72 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 8.66 |
| CHEMBL1391421 | — | — | 1 | 7.22 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 6.62 |
| CHEMBL265941 | ACETAMIPRID | — | 1 | 6.17 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3 | NICOTINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1391421 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL451432 | THIACLOPRID | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL265941 | ACETAMIPRID | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL406819 | IMIDACLOPRID | Ki | = | 970.0 | nM | 6.01 |