Assay Detail
Binding
CHEMBL3071785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Homo sapiens (human) recombinant GSK3beta after 30 min by Kinase-Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavonoids as lead compounds modulating the enzyme targets in Alzheimers disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.88 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.82 |
| CHEMBL28 | APIGENIN | — | 1 | 5.72 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.70 |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | 4.57 |
| CHEMBL9352 | NARINGENIN | — | 1 | 4.34 |
| CHEMBL451532 | NARINGIN | — | 1 | 4.00 |
| CHEMBL449317 | HESPERIDIN | 3.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL28 | APIGENIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL399121 | HESPERETIN | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL451532 | NARINGIN | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL449317 | HESPERIDIN | IC50 | = | 100000.0 | nM | 4.00 |