Assay Detail
Binding
CHEMBL3072144
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Inhibition of cathepsin D (unknown origin) using hemoglobin as substrate after 30 min by spectrophotometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Cathepsin D protease activity by Punica granatum fruit peel extracts, isolates, and semisynthetic analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.71 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221543 | BETA-SITOSTENONE | — | 1 | 5.03 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.74 |
| CHEMBL43185 | PIPERINE | 2.0 | 1 | 4.37 |
| CHEMBL487887 | URSONIC ACID | — | 1 | - |
| CHEMBL260673 | METHYL URSOLATE | — | 1 | - |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221543 | BETA-SITOSTENONE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL43185 | PIPERINE | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 6.41 | ug.mL-1 | - |
| CHEMBL260673 | METHYL URSOLATE | IC50 | = | 4.45 | ug.mL-1 | - |
| CHEMBL296588 | PEPSTATIN | IC50 | = | 0.0016 | ug.mL-1 | - |