Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3072450

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibition of rape root growth
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Brassica rapa subsp. oleifera
Confidence 1 — Organism
Curated By Autocuration

Target

Brassica rapa subsp. oleifera (CHEMBL2366828)
Type ORGANISM
Organism Brassica rapa subsp. oleifera

Publication

α-(Substituted-phenoxyacetoxy)-α-heterocyclylmethylphosphonates: synthesis, herbicidal activity, inhibition on pyruvate dehydrogenase complex (PDHc), and application as postemergent herbicide against broadleaf weeds.
He HW, Peng H, Wang T, Wang C, Yuan JL, Chen T, He J, Tan X.
J Agric Food Chem (2013) 61 : 2479 -2488
PubMed 23398199 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.37 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2227911 CLACYFOS 1 7.46
CHEMBL2253413 1 7.40
CHEMBL2253447 1 7.38
CHEMBL367623 2,4-DICHLOROPHENOXYACETIC ACID 1 7.25
CHEMBL2289471 1 -
CHEMBL2289470 1 -
CHEMBL2289469 1 -
CHEMBL2289468 1 -
CHEMBL2289467 DIMETHYL ACETYLPHOSPHONATE 1 -
CHEMBL2289466 DIMETHYL 1-HYDROXYETHYLPHOSPHONATE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2227911 CLACYFOS IC50 = 34.4 nM 7.46
CHEMBL2253413 IC50 = 39.6 nM 7.40
CHEMBL2253447 IC50 = 41.8 nM 7.38
CHEMBL367623 2,4-DICHLOROPHENOXYACETIC ACID IC50 = 55.6 nM 7.25
CHEMBL2289471 IC50 = 3245000.0 nM -
CHEMBL2289470 IC50 > 4672000.0 nM -
CHEMBL2289469 IC50 = 236848.0 nM -
CHEMBL2289468 IC50 > 4672000.0 nM -
CHEMBL2289467 DIMETHYL ACETYLPHOSPHONATE IC50 = 1875671.0 nM -
CHEMBL2289466 DIMETHYL 1-HYDROXYETHYLPHOSPHONATE IC50 = 2404248.0 nM -