Assay Detail
Binding
CHEMBL3072453
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Inhibition of Pisum sativum (pea) PDHc by spectrophotometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pisum sativum |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
α-(Substituted-phenoxyacetoxy)-α-heterocyclylmethylphosphonates: synthesis, herbicidal activity, inhibition on pyruvate dehydrogenase complex (PDHc), and application as postemergent herbicide against broadleaf weeds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.65 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2253413 | — | — | 1 | 5.16 |
| CHEMBL2227911 | CLACYFOS | — | 1 | 4.74 |
| CHEMBL2253447 | — | — | 1 | 4.55 |
| CHEMBL2289235 | SODIUM METHYL ACETYLPHOSPHONATE | — | 1 | 4.16 |
| CHEMBL2289471 | — | — | 1 | - |
| CHEMBL2289470 | — | — | 1 | - |
| CHEMBL367623 | 2,4-DICHLOROPHENOXYACETIC ACID | — | 1 | - |
| CHEMBL2289465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2253413 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL2227911 | CLACYFOS | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL2253447 | — | IC50 | = | 28250.0 | nM | 4.55 |
| CHEMBL2289235 | SODIUM METHYL ACETYLPHOSPHONATE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2289471 | — | IC50 | = | 389000.0 | nM | - |
| CHEMBL2289470 | — | IC50 | > | 4670000.0 | nM | - |
| CHEMBL367623 | 2,4-DICHLOROPHENOXYACETIC ACID | IC50 | > | 4530000.0 | nM | - |
| CHEMBL2289465 | — | IC50 | > | 2300000.0 | nM | - |