Assay Detail
Binding
CHEMBL3072501
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Inhibition of Populus sieboldii x Populus grandidentata trans-cinnamate 4-hydroxylase assessed as p-coumaric acid level
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Populus sieboldii x Populus grandidentata |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trans-cinnamate 4-monooxygenase (CHEMBL2268005) ↗| Type | SINGLE PROTEIN |
| Organism | Populus kitakamiensis |
Publication
Inhibition of trans-Cinnamate 4-Hydroxylase by 4-Amino-5-aryl-2,3-dihydro-3H-1,2,4-triazole-3-thiones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.07 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016643 | — | — | 1 | 6.50 |
| CHEMBL2287697 | — | — | 1 | 5.44 |
| CHEMBL2287696 | — | — | 1 | 5.41 |
| CHEMBL2287698 | — | — | 1 | 5.30 |
| CHEMBL571510 | — | — | 1 | 4.89 |
| CHEMBL2287699 | — | — | 1 | 4.35 |
| CHEMBL2287700 | — | — | 1 | 4.35 |
| CHEMBL1630860 | — | — | 1 | 4.29 |
| CHEMBL1163264 | — | — | 1 | - |
| CHEMBL2287694 | — | — | 1 | - |
| CHEMBL2287695 | — | — | 1 | - |
| CHEMBL2285694 | — | — | 1 | - |
| CHEMBL1548655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016643 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2287697 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2287696 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2287698 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL571510 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2287699 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2287700 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1630860 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1163264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2287694 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2287695 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2285694 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1548655 | — | IC50 | > | 100000.0 | nM | - |