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Assay Detail

CHEMBL3072745

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Functional
Anticancer activity against Homo sapiens (human) HBL100 cells after 72 hr by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HBL-100
Confidence 1 — Organism
Curated By Autocuration

Target

HBL-100 (CHEMBL614811)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis antimicrobial and anticancer activity of N-arylmethylidene-piperazine-1-carbothiohydrazide
Kulandaivelu U, Shireesha B, Mahesh C, Vidyasagar JV, Rao TR, Jayaveera KN, Saiko P, Graser G, Szekeres T, Jayaprakash V
Med Chem Res (2013) 22 : 2802 -2808
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.30 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL34259 METHOTREXATE 4.0 1 7.40
CHEMBL2296995 1 6.75
CHEMBL2297002 1 6.58
CHEMBL2297000 1 6.54
CHEMBL2297230 1 6.47
CHEMBL2296996 1 6.27
CHEMBL2297003 1 6.10
CHEMBL2296997 1 6.00
CHEMBL2296999 1 5.80
CHEMBL2296998 1 5.79
CHEMBL2297001 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL34259 METHOTREXATE IC50 = 40.0 nM 7.40
CHEMBL2296995 IC50 = 180.0 nM 6.75
CHEMBL2297002 IC50 = 260.0 nM 6.58
CHEMBL2297000 IC50 = 290.0 nM 6.54
CHEMBL2297230 IC50 = 340.0 nM 6.47
CHEMBL2296996 IC50 = 540.0 nM 6.27
CHEMBL2297003 IC50 = 800.0 nM 6.10
CHEMBL2296997 IC50 = 990.0 nM 6.00
CHEMBL2296999 IC50 = 1600.0 nM 5.80
CHEMBL2296998 IC50 = 1620.0 nM 5.79
CHEMBL2297001 IC50 = 2410.0 nM 5.62