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Assay Detail

CHEMBL3073658

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human coxsackievirus B2 infected in African green monkey Vero 76 cells assessed as reduction in plaque number treated after viral infection measured after 3 days by plaque reduction assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Coxsackievirus B2
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Coxsackievirus B2 (CHEMBL613202)
Type ORGANISM
Organism Coxsackievirus B2

Publication

Syntheses and in vitro biological screening of 1-aryl-10H-[1,2,4]triazolo[3,4:3,4][1,2,4]triazino[5,6-b]indoles
Upadhyay K, Manvar A, Loddo R, Colla PL, Virsodiya V, Trivedi J, Chaniyara R, Shah A
Med Chem Res (2013) 22 : 3675 -3686
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 4.32 4.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE 1 4.64
CHEMBL2296712 1 4.00
CHEMBL2296722 1 -
CHEMBL2296721 1 -
CHEMBL2296720 1 -
CHEMBL2296719 1 -
CHEMBL2295851 1 -
CHEMBL2296718 1 -
CHEMBL2296717 1 -
CHEMBL2296716 1 -
CHEMBL2296715 1 -
CHEMBL2296714 1 -
CHEMBL2296711 1 -
CHEMBL2296710 1 -
CHEMBL2296709 1 -
CHEMBL2296708 1 -
CHEMBL2296707 1 -
CHEMBL2296706 1 -
CHEMBL2296705 1 -
CHEMBL2296704 1 -
CHEMBL2296703 1 -
CHEMBL2296702 1 -
CHEMBL2296713 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE EC50 = 23000.0 nM 4.64
CHEMBL2296712 EC50 = 100000.0 nM 4.00
CHEMBL2296722 EC50 > 100000.0 nM -
CHEMBL2296721 EC50 > 100000.0 nM -
CHEMBL2296720 EC50 > 80000.0 nM -
CHEMBL2296719 EC50 > 100000.0 nM -
CHEMBL2295851 EC50 > 100000.0 nM -
CHEMBL2296718 EC50 > 70000.0 nM -
CHEMBL2296717 EC50 > 60000.0 nM -
CHEMBL2296716 EC50 > 20000.0 nM -
CHEMBL2296715 EC50 > 65000.0 nM -
CHEMBL2296714 EC50 > 15000.0 nM -
CHEMBL2296711 EC50 > 100000.0 nM -
CHEMBL2296710 EC50 > 100000.0 nM -
CHEMBL2296709 EC50 > 100000.0 nM -
CHEMBL2296708 EC50 > 100000.0 nM -
CHEMBL2296707 EC50 > 100000.0 nM -
CHEMBL2296706 EC50 > 100000.0 nM -
CHEMBL2296705 EC50 > 100000.0 nM -
CHEMBL2296704 EC50 > 90000.0 nM -
CHEMBL2296703 EC50 > 100000.0 nM -
CHEMBL2296702 EC50 > 100000.0 nM -
CHEMBL2296713 EC50 > 80000.0 nM -