Assay Detail
Binding
CHEMBL3073886
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Binding affinity to Homo sapiens (human) dopamine D4.4 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Action of benzimidazolo-piperazinyl derivatives on dopamine receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.19 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2298810 | — | — | 1 | 8.77 |
| CHEMBL2298809 | — | — | 1 | 8.59 |
| CHEMBL2298812 | — | — | 1 | 8.54 |
| CHEMBL314952 | — | — | 1 | 8.52 |
| CHEMBL330108 | — | — | 1 | 8.06 |
| CHEMBL315864 | — | — | 1 | 7.84 |
| CHEMBL2298808 | — | — | 1 | 7.83 |
| CHEMBL2298811 | — | — | 1 | 7.33 |
| CHEMBL88365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2298810 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2298809 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL2298812 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL314952 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL330108 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL315864 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL2298808 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL2298811 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL88365 | — | Ki | > | 400.0 | nM | - |