Assay Detail
Binding
CHEMBL3073918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Electrophorus electricus (electric eel) AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 15 min prior to substrate addition measured every 45 s by colorimetric Ellman's method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anticholinesterase activity of fumaramide derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.19 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296122 | — | — | 1 | 6.85 |
| CHEMBL2296126 | — | — | 1 | 6.01 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 5.99 |
| CHEMBL2296101 | — | — | 1 | 5.88 |
| CHEMBL2296116 | — | — | 1 | 5.65 |
| CHEMBL2296120 | — | — | 1 | 5.62 |
| CHEMBL2296121 | — | — | 1 | 5.60 |
| CHEMBL2295846 | — | — | 1 | 5.35 |
| CHEMBL2296123 | — | — | 1 | 5.09 |
| CHEMBL2296114 | — | — | 1 | 4.95 |
| CHEMBL2296111 | — | — | 1 | 4.93 |
| CHEMBL2296119 | — | — | 1 | 4.90 |
| CHEMBL237223 | N-BENZYLANILINE | — | 1 | 4.89 |
| CHEMBL2296115 | — | — | 1 | 4.86 |
| CHEMBL2296125 | — | — | 1 | 4.75 |
| CHEMBL2296124 | — | — | 1 | 4.62 |
| CHEMBL2296112 | — | — | 1 | 4.53 |
| CHEMBL2296113 | — | — | 1 | 4.49 |
| CHEMBL2296117 | — | — | 1 | 4.45 |
| CHEMBL2296118 | — | — | 1 | 4.37 |
| CHEMBL2296108 | — | — | 1 | - |
| CHEMBL2296107 | — | — | 1 | - |
| CHEMBL2296106 | — | — | 1 | - |
| CHEMBL1993147 | — | — | 1 | - |
| CHEMBL2296105 | — | — | 1 | - |
| CHEMBL2296104 | — | — | 1 | - |
| CHEMBL237424 | N-BENZYL-4-METHYLANILINE | — | 1 | - |
| CHEMBL493222 | — | — | 1 | - |
| CHEMBL2296103 | — | — | 1 | - |
| CHEMBL2296102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296122 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2296126 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2296101 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2296116 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL2296120 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL2296121 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL2295846 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2296123 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL2296114 | — | IC50 | = | 11170.0 | nM | 4.95 |
| CHEMBL2296111 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL2296119 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL237223 | N-BENZYLANILINE | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL2296115 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL2296125 | — | IC50 | = | 17720.0 | nM | 4.75 |
| CHEMBL2296124 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL2296112 | — | IC50 | = | 29380.0 | nM | 4.53 |
| CHEMBL2296113 | — | IC50 | = | 32160.0 | nM | 4.49 |
| CHEMBL2296117 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL2296118 | — | IC50 | = | 43080.0 | nM | 4.37 |
| CHEMBL2296110 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296099 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296100 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296109 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237233 | N-BENZYL-4-METHOXYANILINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL493222 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237424 | N-BENZYL-4-METHYLANILINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296105 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1993147 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296106 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296108 | — | IC50 | > | 100000.0 | nM | - |