Assay Detail
Functional
CHEMBL3074358
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Cytotoxicity against Homo sapiens (human) HeLa cells assessed as growth inhibition after 96 hr by coulter counter analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-<i>N</i>-substituted-hydrazinecarbothioamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.01 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.68 |
| CHEMBL2296647 | — | — | 1 | 5.36 |
| CHEMBL2296646 | — | — | 1 | 5.12 |
| CHEMBL2296654 | — | — | 1 | 5.08 |
| CHEMBL2296652 | — | — | 1 | 5.07 |
| CHEMBL2296651 | — | — | 1 | 5.04 |
| CHEMBL2296648 | — | — | 1 | 4.92 |
| CHEMBL2296649 | — | — | 1 | 4.47 |
| CHEMBL2296653 | — | — | 1 | 4.36 |
| CHEMBL2296650 | — | — | 1 | - |
| CHEMBL2296655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2296647 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2296646 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2296654 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2296652 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2296651 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2296648 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2296649 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2296653 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2296650 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL2296655 | — | IC50 | = | 123000.0 | nM | - |