Assay Detail
Functional
CHEMBL3074950
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Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reduced Lantadenes A and B: semi-synthetic synthesis, selective cytotoxicity, apoptosis induction and inhibition of NO, TNF- production in HL-60 cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.80 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2413416 | Reduced Lantadene B | — | 1 | 5.28 |
| CHEMBL2413417 | Reduced Lantadene A | — | 1 | 5.22 |
| CHEMBL510691 | LANTADENE A | — | 1 | 4.59 |
| CHEMBL555367 | LANTADENE B | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2413416 | Reduced Lantadene B | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2413417 | Reduced Lantadene A | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL510691 | LANTADENE A | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL555367 | LANTADENE B | IC50 | = | 81400.0 | nM | 4.09 |