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Assay Detail

CHEMBL3075227

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Mus musculus (mouse) B16 cells assessed as growth inhibition after 72 hr by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16
Confidence 1 — Organism
Curated By Autocuration

Target

B16 (CHEMBL381)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, cytotoxicity, and structureactivity insight of NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidones
Gregory M, Dandavati A, Lee M, Tzou S, Savagian M, Brien KA, Satam V, Patil P, Lee M
Med Chem Res (2013) 22 : 5588 -5597
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.38 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2297364 1 6.70
CHEMBL2297363 1 6.52
CHEMBL2386416 1 6.16
CHEMBL2297176 1 5.82
CHEMBL2297365 1 5.72
CHEMBL2297366 1 5.68
CHEMBL2297361 1 5.52
CHEMBL2297367 1 5.48
CHEMBL2297179 1 5.44
CHEMBL99296 1 5.42
CHEMBL358894 1 5.42
CHEMBL347880 1 5.40
CHEMBL154880 1 5.39
CHEMBL2386413 1 5.19
CHEMBL2297173 1 5.14
CHEMBL2297177 1 4.63
CHEMBL2297362 1 4.60
CHEMBL484992 1 4.49
CHEMBL2297175 1 4.48
CHEMBL2297174 1 4.36
CHEMBL2079269 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2297364 IC50 = 200.0 nM 6.70
CHEMBL2297363 IC50 = 300.0 nM 6.52
CHEMBL2386416 IC50 = 700.0 nM 6.16
CHEMBL2297176 IC50 = 1500.0 nM 5.82
CHEMBL2297365 IC50 = 1900.0 nM 5.72
CHEMBL2297366 IC50 = 2100.0 nM 5.68
CHEMBL2297361 IC50 = 3000.0 nM 5.52
CHEMBL2297367 IC50 = 3300.0 nM 5.48
CHEMBL2297179 IC50 = 3600.0 nM 5.44
CHEMBL99296 IC50 = 3800.0 nM 5.42
CHEMBL358894 IC50 = 3800.0 nM 5.42
CHEMBL347880 IC50 = 4000.0 nM 5.40
CHEMBL154880 IC50 = 4100.0 nM 5.39
CHEMBL2386413 IC50 = 6500.0 nM 5.19
CHEMBL2297173 IC50 = 7300.0 nM 5.14
CHEMBL2297177 IC50 = 23500.0 nM 4.63
CHEMBL2297362 IC50 = 25000.0 nM 4.60
CHEMBL484992 IC50 = 32500.0 nM 4.49
CHEMBL2297175 IC50 = 33000.0 nM 4.48
CHEMBL2297174 IC50 = 44000.0 nM 4.36
CHEMBL2079269 IC50 > 100000.0 nM -