Assay Detail
Binding
CHEMBL3075342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Homo sapiens (human) aldose reductase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Challenges in docking 2-hydroxy and 2,4-dihydroxychalcones into the binding site of ALR2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.03 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 6.43 |
| CHEMBL1020 | TOLMETIN | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15770 | SULINDAC | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1020 | TOLMETIN | IC50 | = | 2390.0 | nM | 5.62 |