Assay Detail
Binding
CHEMBL3076136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.40 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 7.51 |
| CHEMBL2270633 | — | — | 1 | 6.00 |
| CHEMBL72675 | — | — | 1 | 5.40 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | — | 1 | 5.22 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 5.00 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.68 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 4.00 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2270633 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL72675 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3 | NICOTINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 270000.0 | nM | - |