Assay Detail
Binding
CHEMBL3076138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta1 nicotinic acetylcholine receptor subunits
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TE-671 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit alpha (CHEMBL4808) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.14 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 6.80 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | — | 1 | 5.22 |
| CHEMBL72675 | — | — | 1 | 5.10 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 4.96 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.68 |
| CHEMBL2270633 | — | — | 1 | 4.09 |
| CHEMBL451432 | THIACLOPRID | — | 1 | - |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL72675 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3 | NICOTINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2270633 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 120000.0 | nM | - |
| CHEMBL406819 | IMIDACLOPRID | IC50 | > | 300000.0 | nM | - |