Assay Detail
Functional
CHEMBL3076451
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Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition after 48 hr by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel AM80 derivatives as antileukemic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.43 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2283043 | — | — | 1 | 5.34 |
| CHEMBL2283048 | — | — | 1 | 5.10 |
| CHEMBL2283042 | — | — | 1 | 4.73 |
| CHEMBL2283050 | — | — | 1 | 4.60 |
| CHEMBL2283052 | — | — | 1 | 4.40 |
| CHEMBL2283058 | — | — | 1 | 4.40 |
| CHEMBL25202 | TAMIBAROTENE | 4.0 | 1 | 4.37 |
| CHEMBL2283053 | — | — | 1 | 4.31 |
| CHEMBL2283060 | — | — | 1 | 4.13 |
| CHEMBL2283054 | — | — | 1 | 4.08 |
| CHEMBL2283049 | — | — | 1 | 4.08 |
| CHEMBL2283044 | — | — | 1 | 4.03 |
| CHEMBL2283059 | — | — | 1 | 4.02 |
| CHEMBL2283056 | — | — | 1 | - |
| CHEMBL2283055 | — | — | 1 | - |
| CHEMBL2283057 | — | — | 1 | - |
| CHEMBL2283051 | — | — | 1 | - |
| CHEMBL2283061 | — | — | 1 | - |
| CHEMBL2283047 | — | — | 1 | - |
| CHEMBL2283046 | — | — | 1 | - |
| CHEMBL2283045 | — | — | 1 | - |
| CHEMBL2283062 | — | — | 1 | - |
| CHEMBL2283041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2283043 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL2283048 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL2283042 | — | IC50 | = | 18610.0 | nM | 4.73 |
| CHEMBL2283050 | — | IC50 | = | 25380.0 | nM | 4.60 |
| CHEMBL2283052 | — | IC50 | = | 39880.0 | nM | 4.40 |
| CHEMBL2283058 | — | IC50 | = | 39560.0 | nM | 4.40 |
| CHEMBL25202 | TAMIBAROTENE | IC50 | = | 42370.0 | nM | 4.37 |
| CHEMBL2283053 | — | IC50 | = | 49140.0 | nM | 4.31 |
| CHEMBL2283060 | — | IC50 | = | 73460.0 | nM | 4.13 |
| CHEMBL2283054 | — | IC50 | = | 84050.0 | nM | 4.08 |
| CHEMBL2283049 | — | IC50 | = | 83680.0 | nM | 4.08 |
| CHEMBL2283044 | — | IC50 | = | 92620.0 | nM | 4.03 |
| CHEMBL2283059 | — | IC50 | = | 95390.0 | nM | 4.02 |
| CHEMBL2283056 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2283055 | — | IC50 | = | 504210.0 | nM | - |
| CHEMBL2283057 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2283051 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2283061 | — | IC50 | = | 294200.0 | nM | - |
| CHEMBL2283047 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2283046 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2283045 | — | IC50 | = | 663790.0 | nM | - |
| CHEMBL2283062 | — | IC50 | = | 247110.0 | nM | - |
| CHEMBL2283041 | — | IC50 | > | 1000000.0 | nM | - |