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Assay Detail

CHEMBL3076994

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Functional
Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay
ChEMBL ↗
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of resveratrolcoumarin hybrid compounds as potential antitumor agents
Shen W, Mao J, Sun J, Sun M, Zhang C
Med Chem Res (2013) 22 : 1630 -1640
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.04 5.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2282869 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-(4-METHOXYSTYRYL)COUMARIN — 1 5.37
CHEMBL2282871 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-(3,5-DIMETHOXYSTYRYL)COUMARIN — 1 5.13
CHEMBL2282860 TRANS-6-(4-METHOXYSTYRYL)-3-PHENYLCOUMARIN — 1 5.13
CHEMBL296411 TRISMETHOXYRESVERATROL — 1 5.08
CHEMBL2282870 CIS-3-(3,4-DIMETHOXYPHENYL)-6-(3,5-DIMETHOXYSTYRYL)COUMARIN — 1 5.05
CHEMBL2282859 CIS-6-(4-METHOXYSTYRYL)-3-PHENYLCOUMARIN — 1 4.96
CHEMBL2282865 TRANS-6-(3,5-DIMETHOXYSTYRYL)-3-(4-METHOXYPHENYL)COUMARIN — 1 4.95
CHEMBL2282862 TRANS-6-(3,5-DIMETHOXYSTYRYL)-3-PHENYLCOUMARIN — 1 4.87
CHEMBL2282867 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-STYRYLCOUMARIN — 1 4.84
CHEMBL2282868 CIS-3-(3,4-DIMETHOXYPHENYL)-6-(4-METHOXYSTYRYL)COUMARIN — 1 -
CHEMBL2282866 CIS-3-(3,4-DIMETHOXYPHENYL)-6-STYRYLCOUMARIN — 1 -
CHEMBL2282864 CIS-6-(3,5-DIMETHOXYSTYRYL)-3-(4-METHOXYPHENYL)COUMARIN — 1 -
CHEMBL2282863 CIS-3-(4-METHOXYPHENYL)-6-STYRYLCOUMARIN — 1 -
CHEMBL2282861 CIS-6-(3,5-DIMETHOXYSTYRYL)-3-PHENYLCOUMARIN — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2282869 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-(4-METHOXYSTYRYL)COUMARIN IC50 = 4230.0 nM 5.37
CHEMBL2282871 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-(3,5-DIMETHOXYSTYRYL)COUMARIN IC50 = 7410.0 nM 5.13
CHEMBL2282860 TRANS-6-(4-METHOXYSTYRYL)-3-PHENYLCOUMARIN IC50 = 7320.0 nM 5.13
CHEMBL296411 TRISMETHOXYRESVERATROL IC50 = 8410.0 nM 5.08
CHEMBL2282870 CIS-3-(3,4-DIMETHOXYPHENYL)-6-(3,5-DIMETHOXYSTYRYL)COUMARIN IC50 = 9000.0 nM 5.05
CHEMBL2282859 CIS-6-(4-METHOXYSTYRYL)-3-PHENYLCOUMARIN IC50 = 10890.0 nM 4.96
CHEMBL2282865 TRANS-6-(3,5-DIMETHOXYSTYRYL)-3-(4-METHOXYPHENYL)COUMARIN IC50 = 11230.0 nM 4.95
CHEMBL2282862 TRANS-6-(3,5-DIMETHOXYSTYRYL)-3-PHENYLCOUMARIN IC50 = 13500.0 nM 4.87
CHEMBL2282867 TRANS-3-(3,4-DIMETHOXYPHENYL)-6-STYRYLCOUMARIN IC50 = 14500.0 nM 4.84
CHEMBL2282868 CIS-3-(3,4-DIMETHOXYPHENYL)-6-(4-METHOXYSTYRYL)COUMARIN IC50 - — -
CHEMBL2282866 CIS-3-(3,4-DIMETHOXYPHENYL)-6-STYRYLCOUMARIN IC50 - — -
CHEMBL2282864 CIS-6-(3,5-DIMETHOXYSTYRYL)-3-(4-METHOXYPHENYL)COUMARIN IC50 - — -
CHEMBL2282863 CIS-3-(4-METHOXYPHENYL)-6-STYRYLCOUMARIN IC50 - — -
CHEMBL2282861 CIS-6-(3,5-DIMETHOXYSTYRYL)-3-PHENYLCOUMARIN IC50 - — -