Assay Detail
Binding
CHEMBL3078038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from nAChR in Periplaneta americana (American cockroach) nerve cords membranes incubated at 24 degC for 2 hr by liquid scintillation counting method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Periplaneta americana |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha8 subunit (CHEMBL2366437) ↗| Type | SINGLE PROTEIN |
| Organism | Periplaneta americana |
Publication
Affinity of 3-benzylidene- and 3-cinnamylidenemyosmine analogues for Periplaneta americana nicotinic acetylcholine receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.09 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2287991 | — | — | 1 | 7.67 |
| CHEMBL1164667 | 3-BENZYLIDENEANABASEINE | — | 1 | 7.46 |
| CHEMBL2287993 | — | — | 1 | 6.92 |
| CHEMBL2287994 | — | — | 1 | 6.51 |
| CHEMBL2287989 | — | — | 1 | 5.68 |
| CHEMBL2287990 | 3-CINNAMYLIDENEMYOSMINE | — | 1 | 5.45 |
| CHEMBL2285697 | — | — | 1 | 5.41 |
| CHEMBL2287997 | — | — | 1 | 5.34 |
| CHEMBL2287988 | — | — | 1 | 5.26 |
| CHEMBL2287996 | — | — | 1 | 5.16 |
| CHEMBL2287985 | — | — | 1 | - |
| CHEMBL2287984 | — | — | 1 | - |
| CHEMBL2287999 | — | — | 1 | - |
| CHEMBL2287998 | — | — | 1 | - |
| CHEMBL2287995 | — | — | 1 | - |
| CHEMBL2287986 | — | — | 1 | - |
| CHEMBL2287987 | — | — | 1 | - |
| CHEMBL2287992 | — | — | 1 | - |
| CHEMBL423429 | MYOSMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2287991 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL1164667 | 3-BENZYLIDENEANABASEINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2287993 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2287994 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2287989 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL2287990 | 3-CINNAMYLIDENEMYOSMINE | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL2285697 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL2287997 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL2287988 | — | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL2287996 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2287985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287984 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287999 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287998 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287995 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287986 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2287992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL423429 | MYOSMINE | IC50 | > | 10000.0 | nM | - |