Assay Detail
Binding
CHEMBL3078145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bos taurus (bovine) heart mitochondrial NADPH oxidase activity assessed per mg protein
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phytotoxic Compounds Cochlioquinones Are Inhibitors of Mitochondrial NADH-Ubiquinone Reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.57 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429023 | ROTENONE | — | 1 | 9.77 |
| CHEMBL2288173 | ISOCOCHLIOQUINONE A | — | 1 | 7.25 |
| CHEMBL2288169 | COCHLIOQUINONE B | — | 1 | 7.08 |
| CHEMBL2288168 | COCHLIOQUINONE A | — | 1 | 6.94 |
| CHEMBL2288178 | STEMPHONE | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429023 | ROTENONE | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL2288173 | ISOCOCHLIOQUINONE A | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2288169 | COCHLIOQUINONE B | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2288168 | COCHLIOQUINONE A | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2288178 | STEMPHONE | IC50 | = | 160.0 | nM | 6.80 |