Assay Detail
Binding
CHEMBL3082109
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Inhibition of Sus scrofa (pig) trehalase using trehaloase as substrate incubated for 15 min prior to substrate addition measured after 1.5 hr by spectrophotometric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and quantitative structure-activity relationships of fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as trehalase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.21 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2270665 | — | — | 1 | 4.45 |
| CHEMBL2270659 | — | — | 1 | 4.12 |
| CHEMBL2270890 | — | — | 1 | 4.07 |
| CHEMBL2270891 | — | — | 1 | - |
| CHEMBL2270889 | — | — | 1 | - |
| CHEMBL2270664 | — | — | 1 | - |
| CHEMBL2270663 | — | — | 1 | - |
| CHEMBL2270662 | — | — | 1 | - |
| CHEMBL2270661 | — | — | 1 | - |
| CHEMBL2270660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2270665 | — | IC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL2270659 | — | IC50 | = | 75857.76 | nM | 4.12 |
| CHEMBL2270890 | — | IC50 | = | 85113.8 | nM | 4.07 |
| CHEMBL2270891 | — | IC50 | = | 707945.78 | nM | - |
| CHEMBL2270889 | — | IC50 | = | 239883.29 | nM | - |
| CHEMBL2270664 | — | IC50 | = | 6165950.02 | nM | - |
| CHEMBL2270663 | — | IC50 | = | 891250.94 | nM | - |
| CHEMBL2270662 | — | IC50 | = | 575439.94 | nM | - |
| CHEMBL2270661 | — | IC50 | = | 263026.8 | nM | - |
| CHEMBL2270660 | — | IC50 | = | 831763.77 | nM | - |