Assay Detail

CHEMBL3083970

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Negative ionotropic activity in electrically-paced Cavia porcellus (guinea pig) right atrium assessed as effect on force measured immediately by isometric transducer analysis in absence of benzalkonium/prazosin

ChEMBL ↗

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Target

Right atrium (CHEMBL2367363) ↗

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Primary target Right atrium

CHEMBL2367363

Anchored from Assay target.

Protein identity Right atrium

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Cardiac atrium
Confidence	1 — Organism
Curated By	Autocuration

Target

Right atrium (CHEMBL2367363) ↗

Type	TISSUE
Organism	Cavia porcellus

Publication

Polyamines May Modulate Both G Protein-Coupled Receptors and G Proteins

Marucci G, Novi F, Banzi R, Bolognesi ML, Buccioni M, Minarini A, Rosini M, Angeli P, Maggio R, Melchiorre C
Med Chem Res (2004) 13 : 63 -73
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.79	8.81

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL130835	PIPERTRAMINE AMIDE	—	1	8.81
CHEMBL128365	ARECAIDINE PROPARGYL ESTER	—	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL130835	PIPERTRAMINE AMIDE	EC50	=	1.549	nM	8.81
CHEMBL128365	ARECAIDINE PROPARGYL ESTER	EC50	=	1.698	nM	8.77