Assay Detail
Binding
CHEMBL3088889
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Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1474387 | — | — | 1 | 8.46 |
| CHEMBL1210313 | — | — | 1 | 8.17 |
| CHEMBL469695 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1474387 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1210313 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL469695 | — | IC50 | = | 25.0 | nM | 7.60 |