Assay Detail
Functional
CHEMBL3088892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.36 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1210313 | — | — | 1 | 8.92 |
| CHEMBL469695 | — | — | 1 | 8.28 |
| CHEMBL1474387 | — | — | 1 | 7.35 |
| CHEMBL3086821 | — | — | 1 | 7.15 |
| CHEMBL3086837 | — | — | 1 | 7.03 |
| CHEMBL3086835 | — | — | 1 | 6.96 |
| CHEMBL3086836 | — | — | 1 | 6.96 |
| CHEMBL3086823 | — | — | 1 | 6.92 |
| CHEMBL3086825 | — | — | 1 | 6.77 |
| CHEMBL3086838 | — | — | 1 | 6.66 |
| CHEMBL3086822 | — | — | 1 | 6.48 |
| CHEMBL3086824 | — | — | 1 | 6.40 |
| CHEMBL3086826 | — | — | 1 | 6.17 |
| CHEMBL1472563 | — | — | 1 | 6.15 |
| CHEMBL3086827 | — | — | 1 | 6.08 |
| CHEMBL1553073 | — | — | 1 | 6.03 |
| CHEMBL3086820 | — | — | 1 | 5.89 |
| CHEMBL3086833 | — | — | 1 | 5.89 |
| CHEMBL1598051 | — | — | 1 | 5.77 |
| CHEMBL3086834 | — | — | 1 | 5.68 |
| CHEMBL1315807 | — | — | 1 | 5.68 |
| CHEMBL1514777 | — | — | 1 | 4.75 |
| CHEMBL3086829 | — | — | 1 | 4.41 |
| CHEMBL1393909 | — | — | 1 | 4.20 |
| CHEMBL1314112 | — | — | 1 | - |
| CHEMBL1701941 | — | — | 1 | - |
| CHEMBL1474508 | — | — | 1 | - |
| CHEMBL3086832 | — | — | 1 | - |
| CHEMBL1589741 | — | — | 1 | - |
| CHEMBL1474223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1210313 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL469695 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1474387 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3086821 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3086837 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3086835 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3086836 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3086823 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3086825 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3086838 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3086822 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3086824 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3086826 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1472563 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3086827 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1553073 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3086820 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3086833 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1598051 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3086834 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1315807 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1514777 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3086829 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1393909 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1314112 | — | IC50 | - | — | - | |
| CHEMBL1701941 | — | IC50 | - | — | - | |
| CHEMBL1474508 | — | IC50 | - | — | - | |
| CHEMBL3086832 | — | IC50 | - | — | - | |
| CHEMBL1589741 | — | IC50 | - | — | - | |
| CHEMBL1474223 | — | IC50 | - | — | - | |
| CHEMBL1394028 | — | IC50 | - | — | - | |
| CHEMBL1719577 | — | IC50 | - | — | - | |
| CHEMBL1358647 | — | IC50 | - | — | - |