Assay Detail
Functional
CHEMBL3089269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.01 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228814 | ISPINESIB | 2.0 | 1 | 5.89 |
| CHEMBL3087419 | — | — | 1 | 5.32 |
| CHEMBL3087420 | — | — | 1 | 5.29 |
| CHEMBL3087418 | — | — | 1 | 5.28 |
| CHEMBL3087430 | — | — | 1 | 5.09 |
| CHEMBL3087429 | — | — | 1 | 5.05 |
| CHEMBL3087428 | — | — | 1 | 5.01 |
| CHEMBL3087426 | — | — | 1 | 5.00 |
| CHEMBL3087427 | — | — | 1 | 4.95 |
| CHEMBL3087425 | — | — | 1 | 4.90 |
| CHEMBL3087416 | — | — | 1 | 4.90 |
| CHEMBL3087421 | — | — | 1 | 4.89 |
| CHEMBL3087417 | — | — | 1 | 4.88 |
| CHEMBL3087422 | — | — | 1 | 4.87 |
| CHEMBL3087414 | — | — | 1 | 4.83 |
| CHEMBL3087423 | — | — | 1 | 4.81 |
| CHEMBL3087415 | — | — | 1 | 4.81 |
| CHEMBL3087424 | — | — | 1 | 4.80 |
| CHEMBL3085794 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228814 | ISPINESIB | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3087419 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3087420 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3087418 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3087430 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3087429 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3087428 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3087426 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3087427 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3087425 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3087416 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3087421 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3087417 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3087422 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3087414 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3087423 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3087415 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3087424 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3085794 | — | IC50 | = | 19800.0 | nM | 4.70 |